Hi Art,
The way I suggest to do this is...
1. On the default IIS Website (port 80) deploy the client apps. When I say client app I mean the PB .EXE portion (not the C# Web APIs). Each client app would be in a subfolder of this default IIS Website.
2. Then create another IIS Website (must be different port than 80, for example 5099) that will hose the multiple Web APIs. Again, just like the client app, each Web API needs to be in a distinct subfolder of this Website. Here are instructions how to do this: https://docs.appeon.com/ps2022/Deploying_multiple_Web_APIs_to_IIS.html
Best regards,
Armeen