You aren't going to get much useful help with such little info.  It would be helpful if you explain:

1. What you exactly mean by not working?  What is error message?

2. Was 64-bit working with previous version of PowerBuilder?

3. With PowerBuilder 2019, does 32-bit compile have the same issue?

Hi Doug;

  Can you create a simple 32 & 64 bit "hello world" App EXE and see if that works OK. Don't forget to also run the PB Packager utility to build both a 32 & 64 bit PB runtime MSI install & run both of these on the Windows 2019 machine before running the PB App EXE's.

Regards ... Chris

Just to update. We re-installed all PB components for 64bit ( must have missed some). 64bit is running on windows2019.