Something went wrong with the PowerBuilder install. You should see this in the registry:

HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Sybase\PowerBuilder\22.0\Vendors

Hi, Amna -

There are two pieces of software that are needed in order for a PB application to communicate with any database:

1. The vendor-supplied database client (SQL Server Native Client, in this case).
2. The Appeon-supplied database interface that it to be used with (Part 1).

As Chris explains, you have installed (Part 1), but do not have any of the various options for (Part 2) installed.

Here is a link to a diagram that illustrates this: https://docs.appeon.com/pb2022r3/connecting_to_your_database/XREF_23761_Basic_software.html

If you are using a more recent version of SQL Server and you decide to purchase PowerBuilder, I suggest you consider using Microsoft's MSOLEDBSQL client instead of SQL Server Native Client (SNC). Microsoft deprecated the SNC client a few years ago and will no longer be providing updates to it. There is also the option of using an ODBC (Open DataBase Connection) driver along with PB's ODBC interface. ODBC works well, but it adds another software layer to the mix: https://docs.appeon.com/pb2022r3/connecting_to_your_database/XREF_22487_About_the_ODBC.html#d0e649

The Community is here to help, so I encourage you to ask additional questions as needed.

Best regards, John

Hi,

in Appen free trial version of 2022, when I click on the DB profile for making database connection

then below message window message. 

Upon click of this ok button then below window comes

Hi Amma;

  Are you referring to trying to connect to SS in the DB Profile Painter in the IDE or when you try to run your app from the IDE / EXE?

Regards... Chris