Hmmm .. that is very weird. I have been on W10 for 4 years and using PB 2017 for about a year now (from starting with 2017 beta). I have had no mouse scrolling issues in the PowerScript Painter (or even my PB Apps') from my perspective on any of my 3 development machines. My PC's are all now on the W10 Fall Creator Edition and running PB 2017 R2.
I wonder if this is a mouse driver issue on your PC?
FWIW: I only use Logitech mice and my PC's are all AMD based processors.