Hi Jay,
Our team has checked and found out, PowerBuilder itself (either 12.6, or the later Appeon versions) are not affected by the MS DCOM issue.
It is possible that a PowerBuilder application may use a DCOM server for OLE features. However, 1) the DCOM server is a feature outside of PowerBuilder product code and installation package, 2) PowerBuilder does not provide any special compatibility/integration for DCOM server, and 3) the security fix for this issue doesn't require PowerBuilder to do something from client-side perspective.
Therefore, please check whether you are using DCOM server with your PowerBuilder application. If not, everything shall be fine. If yes, please follow the suggestion given by Microsoft at https://support.microsoft.com/en-us/topic/kb5004442-manage-changes-for-windows-dcom-server-security-feature-bypass-cve-2021-26414-f1400b52-c141-43d2-941e-37ed901c769c to mitigate the issue.
Best regards, Julie