The information contained within in the link that Govinda provided contains the answer, but you have to ferret it out.
In a quick test, I tried to execute the PowerScript command Run('C:\Windows\system32\osk.exe') and at runtime I get a "Could not start On-Screen Keyboard) message box. It fails because I'm running my test PB app from the IDE (therefore, it is a 32-bit process), and on my 64-bit Windows OS, the executables in the System32 folder are 64-bit.
When I change the command to 'C:\Windows\sysnative\osk.exe', the On-Screen Keyboard app opens and I can use it to send keystrokes to a DataWindow in my test app. The "sysnative" keyword is a virtual folder that signals windows to bypass file system redirection, so Windows looks (and executes) the osk.exe from the SysWOW64 folder, which is where the 32-bit version of system executables reside. Curiously, an attempt to run the osk.exe directly from the SysWOW64 folder fails. Oh, well. using "sysnative" appears to do the trick.
Please note that the "sysnative" alias should only be used from a 32-bit application. It should not be used from a 64-bit application.
HTH, John