Hi mathews,
Does the application work well on Firefox/IE? If only Chrome/Edge have the issue, it should be caused by an Chromium security update. PowerServer application requires to access local service http://127.0.0.1, but this update does not allow remote site access the local resource via http connection, please refer to the article below for details.
https://developer.chrome.com/blog/private-network-access-update/
Please try any solutions below to work around the issue .
1. Start application via Firefox/IE.
2. Install the certificate on web server and use the https connection to access the application, for example:
https://%server%/%applicaiton%
3. Disable 'Block insecure private network requests' in Chrome/Edge.
https://stackoverflow.com/questions/66534759/chrome-cors-error-on-request-to-localhost-dev-server-from-remote-site
Regards,
Kai